Análisis de reacciones in situ ReactIR

Las mediciones continuas a partir de los espectrómetros infrarrojos se usan bastante para obtener perfiles de reacción con el fin de calcular velocidades de reacción. Una lista de publicaciones de revistas con revisión científica se centra en interesantes aplicaciones novedosas de la espectroscopia FTIR. Los investigadores de los entornos académicos e industriales usan los espectrómetros FTIR de infrarrojos de onda media in situ para proporcionar información exhaustiva y datos experimentales completos que les permitan avanzar en sus investigaciones.

1. Bass, TM, Zell, D., Kelly, SM, Malig, TC, Napolitano, JG, Sirois, LE, Han, C. y Gosselin, F. (2024). Scalable Synthesis of 6-Chloro-1H-pyrazolo[3,4-b]pyrazine via a Continuous Flow Formylation/Hydrazine Cyclization Cascade. Organic Process Research & Development. https://doi.org/10.1021/acs.oprd.4c00047
   
2. Dijkmans, J., Chau, J., Maes, T., Khamiakova, T., Laps, S. y Vandervoort, N. (2024). Generative PAT Fingerprint Approach for verification of the Scale-Up of pharmaceutical Processes. Organic Process Research & Development, 28(3), 770–779. https://doi.org/10.1021/acs.oprd.3c00500
3. Fairlamb, IJS y Lynam, JM (2024). Unveiling mechanistic complexity in Manganese-Catalyzed C–H bond functionalization using IR spectroscopy over 16 orders of magnitude in time. Accounts of Chemical Research, 57(6), 919–932. https://doi.org/10.1021/acs.accounts.3c00774
4. He, Y., Hua, K. y Lu, Y. (2023). Alcoholysis of ethylene-vinyl acetate copolymer catalyzed by alkaline: A kinetic study based on in situ FTIR spectroscopy. Chemical Engineering Journal, 464, 142695. https://doi.org/10.1016/j.cej.2023.142695
   
5. Ni, L., Yang, S., Qiu, W., Jin, J., Xu, Q. y Ye, S. (2023). Mechanism study of the N-butoxycarbonyl-2,5-dimethylpyrrole synthesis reaction based on in-situ FTIR monitoring. Vibrational Spectroscopy, 103558. https://doi.org/10.1016/j.vibspec.2023.103558
6. Liu, J., Sato, Y., Yang, F., Kukor, A. J. y Hein, J. E. (2022). An Adaptive Auto‐Synthesizer using Online PAT Feedback to Flexibly Perform a Multistep Reaction. Chemistry Methods, 2(8). https://doi.org/10.1002/cmtd.202200009
7. Naserifar, S., Kuijpers, P. F., Wojno, S., Kádár, R., Bernin, D. y Hasani, M. (2022). In situ monitoring of cellulose etherification in solution: probing the impact of solvent composition on the synthesis of 3-allyloxy-2-hydroxypropyl-cellulose in aqueous hydroxide systems. Polymer Chemistry, 13(28), 4111–4123. https://doi.org/10.1039/d2py00231k
8. Talicska, C. N., O’Connell, E. C., Ward, H. W., Diaz, A., Hardink, M., Foley, D. P., Connolly, D., Girard, K. P. y Ljubicic, T. (2022). Process analytical technology (PAT): applications to flow processes for active pharmaceutical ingredient (API) development. Reaction Chemistry and Engineering, 7(6), 1419–1428. https://doi.org/10.1039/d2re00004k
9. Wei, B., Sharland, J. C., Blackmond, D. G., Musaev, D. G. y Davies, H. M. L. (2022). In Situ Kinetic Studies of Rh(II)-Catalyzed C–H Functionalization to Achieve High Catalyst Turnover Numbers. ACS Catalysis, 12(21), 13400–13410. https://doi.org/10.1021/acscatal.2c04115
10. Foth, P. J., Malig, T. C., Yu, H., Bolduc, T. G., Hein, J. E. y Sammis, G. M. (2020). Halide-Accelerated Acyl Fluoride Formation Using Sulfuryl Fluoride. Organic Letters, 22(16), 6682–6686. https://doi.org/10.1021/acs.orglett.0c02566
11. Yang, L., Zhang, Y., Cheng, J. y Yang, C. (2019). Solubility and thermodynamics of polymorphic indomethacin in binary solvent mixtures. Journal of Molecular Liquids, 295, 111717. https://doi.org/10.1016/j.molliq.2019.111717
12. Ye, J., Jiang, Y., Sheng, T. y Sun, S. (2016). In-situ FTIR spectroscopic studies of electrocatalytic reactions and processes. Nano Energy, 29, 414–427. https://doi.org/10.1016/j.nanoen.2016.06.023
13. Doki, N., Seki, H., Takano, K., Asatani, H., Yokota, M. y Kubota, N. (2004). Process Control of Seeded Batch Cooling Crystallization of the Metastable α-Form Glycine Using an In-Situ ATR-FTIR Spectrometer and an In-Situ FBRM Particle Counter. Crystal Growth & Design, 4(5), 949–953. https://doi.org/10.1021/cg030070s