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Home Automated Lab Reactors, In-Situ Analysis, and Modeling Software Scale‑up Suite

Scale‑up Suite

Chemical Process Modeling Software for Scientists and Engineers

Scale-up Suite™ is a leading supplier of process development software for the global pharmaceutical and chemical industries worldwide. It offers reliable models covering all key unit operations, from reaction kinetics to product isolation, spanning lab to plant scales. This comprehensive approach accelerates development, optimizes processes, and ensures robust scale-up.

Included in Scale-up Suite are Dynochem®, Reaction Lab™, and Dynochem Biologics™, forming a versatile software package designed for routine calculations and dynamic process simulations. Users benefit from extensive material property databases, intuitive tools for daily tasks, ready-made template models, and a customizable platform for complex system modeling. Supported by expert user assistance and training, Scale-up Suite empowers companies to gain deep process understanding and achieve consistent manufacturing success.

Discover how Scale-up Suite can transform your process development. Contact us today!

scale-up suite software
See how Scale-up Suite can benefit your company. Contact us today!
reaction lab software thumbnail

Intelligently Design Reactions

Optimize reactions faster with fewer experiments

Leverage mechanistic models to predict optimal conditions that maximize yield and minimize impurities in synthetic organic processes. Quickly convert process, PAT, and offline analytical data into kinetic models that deepen reaction understanding while conserving time and materials. Extract meaningful insights from your data to accelerate development and provide critical guidance. Gain insight of reaction mechanisms to enable optimal process design. Build confidence in scale-up through data-driven, prediction-based approaches. Advance greener, high-performance chemistry to support your sustainability goals.

Learn more about Reaction Lab.

dynochem scale-up

Right First Time Scale-Up

Optimize scale-up from lab to plant by accurately predicting performance of every unit operation before each campaign

Predict mixing effects on reactions and crystallizations across scales and vessel types. Streamline tech transfer and enhance collaboration with manufacturing partners. Design safer processes by forecasting key parameters such as time to maximum rate (TMR) and maximum temperature of synthesis reaction (MTSR). Develop dynamic models for common chemical unit operations—including reactions, solvent exchange distillation, extractions, filtrations, and drying—to build process knowledge that supports effective scale-up and technology transfer. Access a comprehensive database of material properties for solvents and chemicals. Perform routine calculations quickly using user-friendly applications like chemical equilibrium, mixing and heat transfer, process fit, and solubility prediction. Utilize an extensive library of simulation tools developed by industry experts, ready for immediate use.

bioprocess scale-up

Bioprocess Modeling at Any Scale

Characterize processes across typical upstream and downstream unit operations

Scale from lab reactors with mixing calculation tools such as Ambr® 15, shake flasks, vials, and rocked/wave bags to stirred tank reactors. Ensure proper mixing without excessive shear in operations from media development and preparation through ultrafiltration/diafiltration, preventing batch failures and yield loss. Develop bioreactor models to predict glucose and dissolved oxygen levels, pH, and titer at each scale, leveraging mixing tools to maintain uniform spatial distribution. Downstream modeling capabilities include disk-stack centrifugation, depth filtration, chromatography, virus inactivation, conjugation, tangential flow filtration (TFF), and diafiltration, with design support for mixing setups. Fill/finish tools predict lyophilization outcomes (primary and secondary drying) in vials, preventing meltback and collapse, while ensuring adequate excipient mixing.

Learn more about Dynochem Biologics.

Case Studies from Industry

Data-Driven Reaction Models in Late-Stage Pharmaceutical Process Development
How Reaction Lab Can Compensate for a Weaker Background in Reaction Kinetics
PAT and Model-Based Approach to Accelerate Biopharma Process Development
Green Solvent Swap Distillation

Webinar: Green Solvent Swap Distillation

Solvent swaps are common operations within a synthetic step to setup the following reaction, extract...

Kinetic Models for Chemical Process Development

Kinetic Modeling of Chemical Reactions

By quantitatively describing the reaction kinetics, kinetic models provide valuable insights into th...

Process Development Heat Flow Data

Understanding Scale-up Risks in Early-Stage Process Development

A best practice during process development involves understanding safety risks associated with a che...

Scale-up of Batch Crystallization From Lab to Plant

Batch Crystallizer Scale-Up and Design

Scale-up of crystallization is notoriously complicated and companies are under pressure to develop s...

Dosing in Chemical Development

Safe, Unattended Dosing in Chemical Development & Scale-up

Grünenthal Process R&D safely automates dosing and runs highly exothermic reactions unattended to in...

Lubrizol Process Development and Scale-up

Lubrizol's Efficient Scale-Up & Process Control

This webinar focuses on how to improve process development and scale-up by leveraging calorimetry an...

Effective Design of Experiment Studies

Effective Design of Experiment Studies

This paper describes the Design of Experiments (DoE) approach and how it is used to identify the rel...

Sustainable Development with Scale-up Suite

METTLER TOLEDO is committed to achieving carbon neutrality and establishing science-based targets to reduce greenhouse gas emissions across our operations and supply chain. Scale-up Suite empowers you to design processes that minimize raw material use, reduce waste generation, and lower energy consumption, resulting in more efficient and high-performing operations.

GreenMT framework

Is Scale-up Systems the same company as METTLER TOLEDO?

As of Friday, October 1st, 2021 Scale-up Systems has become part of the METTLER TOLEDO Group. Our organization will join the METTLER TOLEDO AutoChem business that is serving many of the same customers in the pharmaceutical industry. We are excited about the opportunities this important step in our company history presents.

The combination of our widely used Scale-up Suite™ process development and scale-up software with METTLER TOLEDO's market-leading products and services for biological and chemical process development creates the most comprehensive offerings for these important applications in the pharmaceutical and chemical industry.

We are committed to continuing to deliver the excellent products and customer support that our customers have come to expect from Scale-up Systems and look forward to adding the global strengths of METTLER TOLEDO.

What is process scale-up and tech transfer?

Process scale-up generally refers to increasing the production capacity by operating a chemical process in larger equipment. For example, transferring a process from the lab scale to a pilot plant or from a pilot plant to a full-scale manufacturing plant. Transferring a process across scales will often impact the physical rates in the synthesis, such as mixing, heat transfer, and mass transfer. Understanding the impact of these rates on a process is critical to designing the process to operate efficiently and robustly while producing quality products at new scales.

Transferring a process into new equipment or sites is generally referred to as a technology transfer (tech transfer) and may involve scale-up, scale-down, or scale-neutral transitions. Our process modeling software in the Scale-up Suite provides an easy-to-use and comprehensive platform for making calculations and performing simulations that can account for the physical rates, ensuring a right first time scale-up and successful tech transfer.

What is the scale-up process?

As a chemical process is developed, more material must be produced to eventually achieve commercial production demands. Often, a chemical process is scaled up several times, over orders of magnitude, from small lab bench scale to medium pilot plant facilities to large full-scale manufacturing plants.

New pharmaceuticals frequently require several scale-ups due to the increasing demands of pre-clinical studies and clinical trials before regulatory approval of the manufacturing process. Achieving quality material at expected yields when transferring a process (right first time) is important to accelerate the development of new processes and the pace of products reaching the market. Our process modeling software in the Scale-up Suite enables you to achieve these goals and accelerate process development while dealing with increasingly complex processes.

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