Each automated and semi-automated liquid dispensing system has its own method of tightly sealing 96 and sometimes 384 pipette tips simultaneously. Some systems require lowering the head over the tips and pushing a button. Other systems sense the head over the tips and automatically initiate secure tip loading.
In general, ensure that you are using the correct tips for the automated pipetting system and the recommended method for loading them.
For the Rainin MicroPro, simply lower the head onto the tips with light pressure, and the system does the rest. For the Rainin BenchSmart 96, lower the pipetting head over the tips and press the up-arrow “load tips” button on the touchscreen. On BenchSmart, you can alternatively push the “up” buttons on the pipetting head to load a rack of pipette tips.