InPro 5000i CO2 Sensor for Bioreactors

In-Line CO2 Measurements for Cell Culture and Fermentation

The InPro 5000i is an online digital sensor for measuring carbon dioxide levels in biopharmaceutical cell culture and fermentation. The InPro 5000i helps you achieve accurate CO2 measurements and real-time process control to optimize bioreactor productivity and support process scale-up. In situ measurement of CO2 with the InPro 5000i allows immediate reaction to changes in CO2 concentration. InPro 5000i is autoclavable and steam sterilizable to meet pharmaceutical cleaning requirements.

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Optimize Bioreactor Productivity

In situ measurements of CO2 with the InPro 5000i allows immediate reaction to dissolved carbon dioxide level changes to help maximize productivity in cell culture and fermentation.

Accurate Measurements with Quick Response Times

The InPro 5000i is designed to help you achieve real-time process control by providing fast response times and high signal stability when measuring bioreactor CO2 levels.

Reliable, Proven Technology for CO2 Measurement

Based on the widely accepted Severinghaus principle of CO2 measurement, the InPro 5000i provides reliable, accurate measurements of carbon dioxide levels in biopharmaceutical applications.

Surface Finish to Prevent Sensor Contamination

With a stainless steel surface finish for use in hygienic environments, the InPro 5000i easily prevents contamination and the sensor is fully sterilizable either in-situ or in an autoclave.

Long Lasting and Easy to Maintain Membranes

The InPro 5000i uses a membrane body concept to limit maintenance time with an interior body electrode that can easily be replaced on site without sending the sensor to be serviced.

EHEDG Certified for Cleanability with Hygienic Design

Offering in situ CO2 measurements, the InPro 5000i is made of FDA positive listed construction materials and is EHEDG certified for optimal cleanability in hygienic environments.

InPro 5000i Offers Advanced ISM Diagnostics

ISM advanced diagnostics are used with this biotechnology CO2 sensor to provide pre-batch diagnostics for high-performance measurements and full traceability for complete documentation.

Useful Related Links

Dissolved CO2 Measurement Theory Guide

CO2 is an important metabolic indicator in bioprocessing applications. It impacts extracellular and intracellular pH and can directly and indirectly impact glycosylation patterns and molecule stability. Read more

Optimizing a Bioreactor Portfolio

This white paper examines the issues that many bioreactor manufacturers face when optimizing a bioreactor portfolio to meet the challenging scale-up requirements of their pharmaceutical clients. Specifically, there are often challenges associated with transferring technology from the laboratory scale to the production scale, as well as the reverse. Read more

Improve Cell Culture Processes

The importance of preventing dissolved CO₂ accumulation and controlling dissolved CO₂ measurement in mammalian cell culture processes is growing in acceptance. Read more

Process Analytics Product Catalog

The METTLER TOLEDO Process Analytics Catalog provides a comprehensive overview of solutions for analytical measurements in liquid process applications, pure water monitoring and gas-phase measurement. Read more

Explore our Services - Tailored to Fit your Equipment

We support and service your measurement equipment through its entire life-cycle, from installation to preventive maintenance and calibration to equipment repair.

FAQs

What is the InPro 5000i?

The InPro 5000i is an online, digital, biotechnology CO2 sensor which measures dissolved carbon dioxide levels in biopharmaceutical applications. These sensors deliver precise, real-time data that increases the understanding of critical fermentation and cell culture processes in order to maximize productivity and reduce service time. The information measured by the dissolved carbon dioxide sensor provides insights into the cellular metabolism and other changes within the bioreactor. InPro 5000i is also integrated with Intelligent Sensor Management (ISM) advanced predictive diagnostics and Plug and Measure technology.

How does the InPro 5000i work?

The METTLER TOLEDO InPro 5000i measures in-line and provides real-time CO2 measurements based on the technology of the Severinghaus principle. The sensing electrode is separated from the measurement medium by an electrolyte-filled chamber with a gas permeable membrane. Carbon dioxide diffuses through the membrane and into the inner electrolyte of the InPro 5000i carbon dioxide sensor, where it equilibrates with bicarbonate ions to alter the pH value. The relative change in pH value of the electrolyte is then measured by an internal pH electrode and correlated to the CO2 level in the medium.

What ISM features are available with the InPro 5000i?

The InPro 5000i digital CO2 sensor uses Intelligent Sensor Management (ISM) technology. This provides many unique features, including pre-batch diagnostics for the best measurement performance, count of sensor exposure to autoclave cycles and full traceability for complete documentation. The Plug and Measure feature also supports seamless biotechnology CO2 sensor integration to your process.

What sensor lengths are available with the InPro 5000i?

The InPro 5000i CO2 sensor by METTLER TOLEDO has 120 mm, 220 mm, and 320 mm sensor lengths available with 12 mm sensor diameter.

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