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Insight into chemical reactions arises from a comprehensive understanding of reaction kinetics, mechanism and the effect of reaction variables on yields and impurity profiles. The need for safer and readily scalable reactions drive changes in how syntheses are performed, as an example, increased adoption of continuous flow methods. The analytical tools available to achieve reaction insight must also advance, driven by the demands to support more complex chemistry and new synthesis protocols. This white paper details the integration of real-time reaction analysis into a robust process analytical technology (PAT) strategy and will give insights into:
Composition Monitoring Technologies: An objective review of the advantages of in-situ techniques, including FTIR, Raman, UV/Vis, NIR, NMR, and MS, for real-time data acquisition.
Advanced Separation Methods: Understanding the role and application of state-of-the-art chromatographic methods for online reaction analysis.
Applications Across Synthetic Disciplines: Strategies for applying these technologies to optimize and control processes in critical areas:
- Organic Synthesis and Catalysis
- Polymerization Kinetics
- Crystallization and Particle Engineering
- Biological Processes and Fermentation Monitoring
- Sustainable and Continuous Flow Chemistry
