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Analytical Chemistry UserCom

Titration, pH, Density, Refractometry, Melting Point, Dropping Point, UV/Vis Spectrophotometry, and Cell Analysis

Home Expertise Library Analytical Chemistry UserCom
Dr. Yvonne Appoldt
Dr. Yvonne Appoldt

Welcome to UserCom — Issue 2: Compliance Made Easy

Meeting regulations shouldn’t drain innovation. This edition curates practical stories, quizzes, and case studies that turn 21 CFR Part 11, USP, Ph. Eur., ISO, and ASTM demands into one-click digital workflows, guided prompts, and automated audit trails.

Inside, five themed sections show compliance in action—from LabX-powered data integrity and pharma QC to distillery alcohol checks, nickel-safe wastewater, and resin softening-point control. Each article offers ready-to-use methods, videos, and downloads that keep your lab inspection-ready while freeing time for discovery.

Thank you for being part of UserCom; explore, learn, and make compliance effortless.

Warm regards,
Yvonne Appoldt

Ready to elevate your analytical chemistry skills today? Click here!

Featured in This Issue

Compliance & Digital Transformation

Compliance & Digital Transformation
Compliance & Digital Transformation

Cutting-Edge Compliance: Inside Our New Laboratory Software

See how integrated LabX workflows erase manual transcription, lock audit trails, and deliver instant, multi-instrument data integrity.

> Read the Feature


21 CFR Part 11: The Hidden Risks of Firmware-Only Compliance

Firmware looks cheap—until gaps in metadata, storage, and ALCOA++ control derail audits. Discover the smarter alternative.

> Find Out More


Standards Simplified: Your Fast-Track to ISO & ASTM Harmony

Navigate thousands of norms in seconds with our searchable database and stop compliance chaos before it starts.

> Explore the Guide

Pharma & Life-Science Quality Control

Pharma & Life-Science Quality Control
Pharma & Life-Science Quality Control

Global Pharma Streamlines Compliance with SevenExcellence + LabX

See how automated pH / conductivity workflows cut transcription errors and prove USP <645> compliance across 30 samples a day—in one click.

> Read Case Study


UV7 + LabX Safeguard Critical Therapeutic QC

Australian site locks down UV/Vis data integrity for an infection-preventing drug using one-button validation and electronic signatures—no spreadsheet drift.

> Learn How


pH in Suspensions: InLab® Max Pro-ISM Answers

Clog-free junctions deliver fast, stable pH for Ibuprofen and Oxcarbazepine suspensions—meeting USP specs with zero sensor downtime.

> Get the Application Note


Pharma Color Testing Simplified with UV7

Replace subjective visual matching; ready-to-use LabX methods give instant pass/fail against USP and Ph. Eur. color standards.

> Explore the Guide

Food & Beverage Industry Applications

Food & Beverage Industry Applications
Food & Beverage Industry Applications

From Glass to Digital: Italian Distillery Turbo-Charges Alcohol Testing

Discover how switching from manual pycnometers to a D6 Density Meter slashed test time to 5 minutes while sharpening accuracy and regulatory confidence.

> Read the Success Story

Environmental & Energy-Materials Testing

Environmental & Energy-Materials Testing
Environmental & Energy-Materials Testing

Nickel in Battery Wastewater: ISO-Compliant UV/Vis Detection

See how a dimethylglyoxime method on EasyPlus UV/Vis quantifies nickel at 445 nm, aligns with ISO 4939:2016, and protects EV manufacturing effluents.

> Read the Application Note

Industrial & Materials Characterization

Industrial & Materials Characterization
Industrial & Materials Characterization

Resin QC Showdown: Cup-&-Ball vs. Ring-&-Ball Softening Tests

Which softening-point method keeps phenolic resins in spec? Explore our head-to-head ASTM study, uncover hidden variances, and choose the safest QC approach.

> Read the Comparison

New Products

Enhancing productivity through Secure, Integrated Solutions

Laboratory Compliance Software – Enhancing productivity through Secure, Integrated Solutions

Elevate lab operations with METTLER TOLEDO’s compliance-focused software. Centralize data, streamline workflows and SOPs, and reduce manual steps. Explore a more efficient path to regulatory compliance. 


> Read More

    Expert Tips

    21 CFR Part 11: Why “Firmware-Only” Solutions May Undermine Your Compliance

    Concerned about data integrity and audit readiness? Discover how relying solely on an instrument’s firmware could leave your lab at risk—and explore a smarter path to compliance. 


    > Read More

          21 CFR Part 11
          21 CFR Part 11
          Find the Right Standards Fast
          Find the Right Standards Fast

          Cut Through Compliance Chaos: Find the Right Standards Fast

          Stay ahead of ISO, ASTM, and other changing lab compliance demands with METTLER TOLEDO’s powerful standards databases—discover essential norms for each instrument quickly and ensure efficient, error-free operations every time.


          > Read More

            Case Study & Testimonial

            How a Global Pharma Achieved Streamlined Compliance with LabX™

            Discover how a major pharmaceutical organization replaced cumbersome manual workflows with automated SevenExcellence and LabX™ processes, strengthening data integrity, reducing errors, and ensuring alignment with USP <645>. 


            > Read More

                        How a Global Pharma Achieved Streamlined Compliance with LabX
                        How a Global Pharma Achieved Streamlined Compliance with LabX
                        How a Global Pharma Company Ensured Secure Spectroscopic Workflows

                        How a Global Pharma Company Ensured Secure Spectroscopic Workflows for Therapeutic Quality

                        Faced with stricter QC for an infection-preventing therapy, a multinational pharmaceutical company upgraded its UV/Vis process using METTLER TOLEDO’s UV7 Excellence Spectrophotometer and LabX™ software to safeguard compliance and data integrity. 


                        > Read More

                            From Glass Pycnometers to Digital Density: How an Italian Distillery Simplified Alcohol Content Testing

                            A family-owned Italian distillery replaced its time-consuming manual process with METTLER TOLEDO’s digital density meter. Discover how these faster, more precise measurements are elevating product quality and supporting regulatory compliance.


                            > Read More

                                        From Glass Pycnometers to Digital Density
                                        From Glass Pycnometers to Digital Density

                                        Applications

                                        Achieving Accurate pH in Pharmaceutical Suspensions
                                        Achieving Accurate pH in Pharmaceutical Suspensions

                                        Achieving Accurate pH in Pharmaceutical Suspensions with InLab Max Pro-ISM

                                        Discover how METTLER TOLEDO’s InLab Max Pro-ISM sensor overcomes clogging issues and delivers reliable pH readings for complex suspensions. Streamline QC workflows and maintain consistent results—especially critical in pharma. 


                                        > Read More

                                            Nickel in Battery Wastewater: Ensuring ISO Compliance

                                            Learn how UV/Vis spectrophotometry helps detect nickel in battery production wastewater. Explore the dimethylglyoxime method’s simplicity, reliability, and alignment with ISO 4939:2016 for safer water management. 


                                            > Read More

                                                  Nickel in Battery Wastewater
                                                  Nickel in Battery Wastewater
                                                  UV7 Spectrophotometer and LabX Software
                                                  UV7 Spectrophotometer and LabX Software

                                                  Compliant Color Testing in Pharma: UV7 Spectrophotometer and LabX™ Software

                                                  Harmonize QC standards with a two-in-one UV/Vis approach that supports USP and Ph. Eur. color determination as well as compliant spectrophotometric measurements. Learn how METTLER TOLEDO’s ready-to-use methods reduce human error and boost consistency. 


                                                  > Read More

                                                    Ensuring Resin Reliability: Comparing Cup-and-Ball (ASTM D6090) vs. Ring-and-Ball (ASTM D 6493)

                                                    Phenol-based resins are only as good as their flow behavior. Dive into a head-to-head comparison of Mettler cup-and-ball (ASTM D 6090/ISO 4625-2) and ring-and-ball (ASTM D 6493/ISO 4625-1) for consistent QC. 


                                                    > Read More

                                                      Ensuring Resin Reliability
                                                      Ensuring Resin Reliability
                                                      Dr. Yvonne Appoldt
                                                      Dr. Yvonne Appoldt

                                                      Yvonne Appoldt heads Analytical Chemistry at METTLER TOLEDO, where she spearheads strategic innovation and guides the unit’s direction.

                                                      Yvonne holds a PhD in Natural Sciences, a Master’s in Biochemistry, and a Master's in Business Administration, equipping her with a unique blend of scientific expertise and business acumen. This combination enables her to drive significant advancements in analytical chemistry, directly contributing to the enhancement of laboratory capabilities on a global scale.

                                                      Live Webinar: Titration Solutions for Wine Analysis

                                                      Live Webinar: Titration Solutions for Wine Analysis

                                                      The webinar on titration in wine covers fundamental concepts of titration, automated titration, and its application in wine analysis.

                                                      Next-Level Speed & Efficiency in Karl Fischer Titration

                                                      Next-Level Speed & Efficiency in Karl Fischer Titration

                                                      Learn from years of experience how to optimize accuracy and repeatability in determining water by Karl Fischer titration by an industry leader.

                                                      Live Webinar: Compliant pH Measurement

                                                      Live Webinar: Compliant pH Measurement

                                                      Join our webinar on pH measurement and compliance to learn about regulatory guidelines and have your compliance questions answered by our experts.

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