EVA Karl Fischer Titrators: Driving Precision and Efficiency Through Automation

Redefining Karl Fischer Titration with EVA’s Predictive Algorithms

Figure 1. EVA Coulometric Karl Fischer titrator combined with InMotion KF autosampler for efficient workflows.

In today’s high-paced lab environments, speed, accuracy, and compliance are no longer optional, they’re expected. Laboratories across pharma, chemicals, biotech, and academia are turning to automation to meet these rising demands while reducing manual workload and errors. The new EVA Karl Fischer Titrator series from METTLER TOLEDO is built with this future in mind. Designed for both coulometric and volumetric applications, the EVA line helps labs streamline water content determination, enhance data integrity, and improve safety, all while saving time.

Figure 1. EVA Coulometric Karl Fischer titrator combined with InMotion KF autosampler for efficient workflows.

Speed Meets Reliability – The Core of EVA KF Titrators

Embodying Swiss craftsmanship, EVA KF titrators are synonymous with reliability and quality. At the heart of EVA KF titrators is the Fast Forecasting Amperometric (FFA™) Algorithm, a breakthrough in control technology. It accelerates iodine generation and reaction rates, dynamically adapting to different chemical systems. This means you get fast, precise results across a wide range of sample types, without constant reagent changes.

Designed with User Convenience In Mind

Built for everyday efficiency, EVA KF titrators feature a modular, plug-and-measure design. Sensors, burettes, and cells can be quickly swapped to match changing workflows, while the newly designed cell with a removable lid simplifies cleaning and minimizes cross-contamination. For added safety, the system includes a closed-loop solvent exchange and a spill-proof cell, drastically reducing operator exposure to chemicals and ensuring smooth, low-maintenance operation.

But EVA goes far beyond the instrument itself. Seamless integration with LabX™ software connects the titrator to your LIMS, ELN, or other enterprise systems. This enables automated data capture, traceable workflows, and compliance with regulatory standards. Your data is stored securely, electronically, and is always audit-ready, no more handwritten logs or risky transcription errors. EVA paired with LabX enables paperless workflows, enhance reproducibility, and minimize errors, leading to reduced resource consumption and solvent usage. With less reagent usage and efficient workflows, your lab benefits from reduced costs and an eco-friendly paperless operations.

Figure 2. Solid sample measurement using EVA Karl Fischer Titrator and InMotion KF Pro as one system.

The Power of Seamless Integration and Automation

For labs looking to boost productivity, EVA pairs perfectly with InMotion™ Autosamplers. Whether you’re running small batches or high-throughput operations, the system enables unattended workflows that free up your team and increase throughput. The EVA V1 and C1 models work seamlessly with the compact 6-position InMotion KF Six autosampler, while the EVA V3 and C3 support the full InMotion KF Flex and Pro range, accommodating up to 25 samples depending on your needs.

When paired with the InMotion KF Oven, EVA becomes the go-to solution for handling solids or viscous samples. This system automatically heats sealed vials and delivers only the released water vapor to the cell - eliminating the need for messy syringe injections and minimizing matrix interferences. Combined with barcode scanning or SmartSample™ RFID, sample info and weights are transferred automatically to the titrator, saving time and preventing errors.

Figure 2. Solid sample measurement using EVA Karl Fischer Titrator and InMotion KF Pro as one system.

Benefits at a Glance

Streamlined Workflows: Automation replaces manual steps, speeding up results while reducing errors.
Enhanced Productivity: Unattended analysis and advanced algorithms ensure faster, more reliable results.
Data Integrity & Compliance: Full LabX integration supports ALCOA++ standards and regulatory compliance.
Reduced Costs: Fewer process deviations, less reagent waste, and faster batch releases.
Improved Safety: Closed systems and smart design reduce chemical exposure and handling risks.
Unmatched Flexibility: Modular hardware and smart software adapt easily to changing lab needs.

Lab automation starts here

With EVA Karl Fischer Titrators, your lab gains the tools to work smarter, stay compliant, and meet growing demands with confidence.

Katja Herter

Katja Herter is the Marketing Manager for Titration at METTLER TOLEDO, leading comprehensive marketing strategies across the entire titration portfolio.

Holding a master’s degree in Health Science and Technology from ETH Zurich, Katja combines her strong technical background with experience in product management and business development, delivering valuable insights that bridge product innovation and market demand.